Process for the preparation of halogenated 15-hydroxy-E-homoeburnane compounds
US4285865A · kind A · utility
1Cited by
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4Claims
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Key dates
| Filing date | Aug 5, 1980 |
| Grant date | Aug 25, 1981 |
| Priority date | — |
| Expiry date | Aug 5, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to new, racemic or optically active, halogenated 15-hydroxy-E-homoeburnane derivatives of the general formula (Ia) and/or (Ib), ##STR1## wherin R is a C.sub.1-6 alkyl group and X is halogen, and acid addition salts thereof. These compounds are biologically active, furthermore they can be applied as intermediates in the synthesis of other pharmaceutically active substances. The compounds of the general formulae (Ia) and (Ib) are prepared by halogenating the respective racemic or optically active 15-hydroxy-E-homoeburnane derivative of the general formula (II), wherein R is as defined above. ##STR2##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.