Enzyme derivatives for use in the treatment of venous thrombosis
US4285932A · kind A · utility
20Cited by
0References
28Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 20, 1979 |
| Grant date | Aug 25, 1981 |
| Priority date | — |
| Expiry date | Aug 20, 1999 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical composition which comprises a pharmaceutically acceptable carrier together with an in vivo fibrinolytic enzyme as defined herein wherein the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis at a rate such that the pseudo-first order rate constant for hydrolysis is in the range 10.sup.-6 sec.sup.-1 to 10.sup.-3 sec.sup.-1 in isotonic aqueous media at pH 7.4 at 37.degree. C.; is useful in the treatment of venous thrombosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.