Xanthene and thioxanthene derivatives, compositions thereof and treatment therewith
US4285956A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 3, 1979 |
| Grant date | Aug 25, 1981 |
| Priority date | — |
| Expiry date | May 3, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel thioxanthene and xanthene derivatives which have useful pharmacodynamic activity, such as neuroleptic activity and antiemetic activity, methods for the preparation of said derivatives, pharmaceutical compositions containing same, and a method for the treatment of psychic disorders by administering a therapeutically active amount of one of said derivatives to a living animal body, including human beings. The new compounds of the present invention correspond to the Formula I: ##STR1## wherein X is a halogen atom, an alkyl group with from one to four carbon atoms inclusive, an alkyloxy group with from one to four carbon atoms inclusive, a methylthio group, a methylsulphonyl group, a dimethylsulfamoyl group, a trifluoromethyl group or an acetyl group; PA1 Y is hydrogen, fluorine or a methyl group; PA1 Z is oxygen or sulphur; PA1 n is an integer from zero to three inclusive, and PA1 R is a cycloalkyl group with from four to six carbon atoms inclusive in the ring substituted with from one to four substituents selected from optionally esterified hydroxy- or hydroxymethyl groups, methyl groups, amino groups, acetamido groups, mesylamino groups or oxo …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.