Antihypertensive 1,4-thiazepine-ones, 1,4-thiazonine-ones, and method of use thereof
US4287203A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 23, 1980 |
| Grant date | Sep 1, 1981 |
| Priority date | — |
| Expiry date | Apr 23, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D281/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Antihypertensive compounds of the structure ##STR1## wherein: n is an integer from 0 to 2 inclusive, PA1 R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are independently hydrogen, alkyl having from 1 to 6 carbon atoms, alkenyl having from 2 to 6 carbon atoms, alkynyl having from 2 to 6 carbon atoms, cycloalkyl having from 3 to 16 carbon atoms, phenyl, benzyl, tolyl, naphthyl, phenethyl, indanyl, tetrahydronaphthyl, decanydronaphthyl, pyridyl, quinolyl, pyrrolidyl, pyrrolyl, morpholinyl, thiomorpholinyl, furyl, furfuryl, tetrahydrofurfuryl, benzimidazole, thienyl, imidolyl, or tetrahydroindolyl, and where the R.sub.1 to R.sub.7 groups are alkyl, said groups carrying a substituent selected from hydroxy, alkoxy, amino, carboxy, or carbalkoxy, the alkyl group in alkoxy and carbalkoxy having from 1 to 6 carbon atoms, or R.sub.2 taken together with R.sub.3 and the carbons to which they are attached is tetrahydronaphthyl or phenyl, and when phenyl R.sub.1 and R.sub.4 are absent, or R.sub.6 and R.sub.7 taken together with the carbon to which R.sub.6 is attached and the nitrogen to which R.sub.7 is attached form a heterocycle selected from pyrrolidyl, thiazolidine, tetrah…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.