Inhibiting adrenergic .beta.-receptors with piperidinopropyl derivatives

US4288442A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Walter-Gunar Friebe · Mannheim, DE
• Helmut Michel · Mannheim, DE
• Carl H. Ross · Viernheim, DE
• Fritz Wiedemann · Weinheim, DE
• Gisbert Sponer · Hemsbach, DE
• Wolfgang Schaumann · Heidelberg, DE

Key dates

• Filing date: Jan 31, 1980
• Grant date: Sep 8, 1981
• Expiry date: Jan 31, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C205/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A piperidinopropyl derivative of the formula ##STR1## in which R.sub.1 and R.sub.2 each independently is hydrogen or a lower alkyl radical, or together are an alkylene radical, PA1 R.sub.3 is hydrogen, hydroxy, or acyloxy, PA1 R.sub.4 is hydrogen or formyl, PA1 A together with the adjacent benzene ring and N-R.sub.4 forms a benzimidazolin-2-one, benzimidazoline-2-thione, oxindole, indazole carbazole, benztriazole, benzimidazole, indoline or indole moiety, and PA1 B is a heterocyclic radical or, under certain circumstances, a phenyl radical, either of which is optionally substituted by halogen, hydroxy, lower alkyl, hydroxy-lower alkyl, carboxamido-lower alkyl, lower alkoxy, amino, carboxamido, lower alkyl-carbonylamino, acyl or lower alkylsulphonylamino, or a pharmacologically acceptable salt thereof. The compounds inhibit adrenergic .beta.-receptors and lower blood pressure.