4-Aminopyridines and medicaments containing the same

US4289765A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wilfried Greve · Rödermark, DE
• Heinzgeorg von Schuh · Wiesbaden, DE
• Hiristo Anagnostopulos · Wiesbaden, DE

Key dates

• Filing date: Jan 7, 1980
• Grant date: Sep 15, 1981
• Expiry date: Jan 7, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/85
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

4-Aminopyridines of the formula ##STR1## in which R.sup.1 is hydrogen or alkyl of up to 6 carbon atoms and PA1 R.sup.2 represents (a) alkyl of up to 6 carbon atoms substituted up to three times with at least one radical from the group of halogen and hydroxyl, with formyl acetalized with an alcohol of up to 3 carbon atoms, alkylthio of up to 3 carbon atoms, phenylthio or the corresponding alkyl- and phenyl-sulfoxy and sulfone groups, the phenyl ring optionally carrying in each case up to three substituents from the group of alkyl, alkyl halide, alkoxy, mono- or dialkylamino having each up to 4 carbon atoms in each alkyl radical, halogen, nitro, amino and hydroxy, or (b) phenylalkyl or diphenyl-alkyl of up to 6 carbon atoms in the linear or branched alkyl moiety, the phenyl rings optionally being substituted up to three times with at least one radical from the group of alkyl, alkoxy, alkyl halide with up to 4 carbon atoms each, halogen, amino, hydroxy, nitro, the sulfamoyl group and the methylene dioxy radical, or PA1 R.sup.1 and R.sup.2, together with the nitrogen atom present in the 4-position, form a five- to seven-membered heterocyclic ring optionally substituted with alkyl of up…