Phenothiazine derivatives and a process for their preparation

US4289768A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Joachim Gante · Darmstadt, DE
• Hans-Eckart Radunz · Darmstadt, DE
• Dieter Orth · Darmstadt, DE
• Hans-Jochen Schliep · Traisa, DE
• Ernst Schorscher · Darmstadt, DE

Key dates

• Filing date: May 2, 1980
• Grant date: Sep 15, 1981
• Expiry date: May 2, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Phenothiazine derivatives of the formula ##STR1## wherein R is H, F, Cl, Br, I, CH.sub.3, CF.sub.3, CN, CH.sub.3 O or CH.sub.3 CO; Y is S, SO, or SO.sub.2 ; Z is imidazol-1-yl, 2-methyl-imidazol-1-yl, pyrazol-1-yl or benzimidazol-1-yl; and n is 1, 2 or 3; or the physiologically acceptable acid addition salts thereof; are useful as antihypertensive agents, for example.