Xanthine derivatives

US4289776A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Werner Mohler · Hofheim, DE
• Manfred Jayme · Gerolzhofen, DE
• Jaromir Komarek · Wiesbaden, DE

Key dates

• Filing date: Apr 23, 1979
• Grant date: Sep 15, 1981
• Expiry date: Apr 23, 1999

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of general formula ##STR1## wherein one of the groups R.sub.1 and R.sub.3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in (.omega.-1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R.sub.2 and the other one of groups R.sub.1 and R.sub.3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R.sub.1 or R.sub.3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.