Technetium-labelled diagnostic agent for the examination of the RES

US4291012A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Helmut Strecker · Seeheim-Jugenheim, DE
• Michael Molter · Dunlap, US
• Gerhard Kloss · Kelkheim, DE
• Eberhard Schickel · Bad Camberg, DE

Key dates

• Filing date: Jan 4, 1979
• Grant date: Sep 22, 1981
• Expiry date: Jan 4, 1999

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process is disclosed for the preparation of a diagnositc agent for scanning the RES, in particular the liver, by mixing the sodium salt of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone in aqueous solution with tin(II) salt, adjusting the solution to a pH between 4 and 9, optionally lyophilizing the mixture and adding .sup.99m Tc-pertechnetate in physiological saline solution.