7-(Oxoalkyl)-1,3-di-n-iso-propyl xanthines and their production

US4291037A · kind A · utility

Assignee

• Johann A. Wulfing · DE

Inventors

• Gunther Brenner · Erkrath, DE
• Joachim Goring · Gronau, DE
• Eskendar Ali Khan · Gronau, DE
• Oskar Rohte
• Manfred Tauscher · Gronau, DE

Key dates

• Filing date: Jun 4, 1979
• Grant date: Sep 22, 1981
• Expiry date: Jun 4, 1999

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

7-(Oxoalkyl)-1,3-dialkyl xanthines whose substituents in the 1- and 3-positions are alkyl groups of 2 to 6 carbons, cyclohexyl, alkoxyalkyl or hydroxyalkyl, such as 7-(3-oxobutyl)-1,3-di-n-butylxanthine, are effective vasodilators, having a marked activity in promoting blood flow through skeletal muscle, while at the same time exhibiting low toxicity.