Cerebral vasodilating 20,21-dinoreburnamenine derivatives
US4291038A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 7, 1980 |
| Grant date | Sep 22, 1981 |
| Priority date | — |
| Expiry date | Apr 7, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New 20,21-dinoreburnamenine derivatives are disclosed which have the formula I ##STR1## wherein the hydroxyl in the 14-position of the molecule is in either of the two possible positions at the carbon atom in the 14-position to which the isomers A and B correspond and the hydrogens in the 3-position and the 16-position of the molecule are in cis- or in trans-position to each other, and their pharmaceutically acceptable acid addition salts, as well as pharmaceutical formulations thereof. The new compounds of formula I are prepared by reducing the corresponding 14-oxoderivatives. They are effective in favorably influencing the cerebral vascular circulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.