Tripeptide inhibitors of angiotensin-converting enzyme
US4293481A · kind A · utility
4Cited by
1References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 24, 1980 |
| Grant date | Oct 6, 1981 |
| Priority date | — |
| Expiry date | Jul 24, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Peptides having the formula ##STR1## wherein R.sub.1 is hydrogen and R.sub.2 is hydroxyl, alkyl, aryl, arylalkyl, alkoxy, alkylthio, aryloxy, arylthio, halogen or azido, or R.sub.1 and R.sub.2 are the same and each is hydrogen, halogen, alkoxy or alkylthio, or R.sub.1 and R.sub.2 together are oxo, --O--(CH.sub.2).sub.n --O--, or --S--(CH.sub.2).sub.n --S--, wherein n is 1 or 2; PA0 R.sub.3 is hydrogen, alkyl or trifluoromethyl; PA0 R.sub.4 is hydrogen or an acyl protecting group; and PA0 R.sub.5 is hydrogen or alkyl; are inhibitors of angiotensin converting enzyme and can be used for the treatment of hypertension in mammals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.