Transdermal medication system for isosorbide dinitrate

US4293565A · kind A · utility

Assignee

• Sanol Schwarz-Monhein GmbH · DE

Inventors

• Gunter Cordes · Leichlingen, DE
• Ewald Giesselmann · Monheim, DE
• Ulrich Munch

Key dates

• Filing date: Oct 9, 1979
• Grant date: Oct 6, 1981
• Expiry date: Oct 9, 1999

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/7023
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A pharmaceutical preparation comprising: PA1 (a) isosorbide dinitrate as active ingredient PA1 (b) a solvent for isosorbide dinitrate PA1 (c) an ointment consistency agent PA1 (d) an emulsifying agent PA1 (e) water, and PA1 (f) possibly customary preservatives, antioxidants, buffers and/or odorants; where the weight ratio of water: consistency agent including emulsifying agent: solvent is 30 to 80: 3 to 35: 3 to 35, the amount of emulsifying agent is from 0% to 15% by weight and the amount of isosorbide dinitrate is from 2% to 20% by weight. The preparation has an ointment-like consistency and is administered topically to the skin, where it has a high adsorption rate and a long duration of response.