Preparation of N-benzyloxycarbonyl aspartic acid
US4293706A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 19, 1980 |
| Grant date | Oct 6, 1981 |
| Priority date | — |
| Expiry date | Jun 19, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C269/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
N-Benzyloxycarbonyl aspartic acid substantially free of N-benzyloxycarbonyl aspartyl aspartic acid is prepared by introducing benzyl chloroformate gradually into an aqueous solution of the disodium salt of aspartic acid at temperatures of between 10.degree. C. and about 45.degree. C. while maintaining the pH of the aqueous solution at between 10.75 and 11.75. In a further embodiment, the mole ratio of unreacted benzyl chloroformate to the aspartic acid salt in the reaction medium is maintained preferably at no greater than 0.2. The resulting reaction mixture is acidified, e.g, with hydrochloric acid, to convert the reaction product to the free acid, which is separated from the reaction mixture, washed with water and dried to yield an essentially pure white granular product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.