Guaiaconic acid A from guaiac resin

US4297271A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Werner Guthlein · Mannheim, DE
• Hans Wielinger · Weinheim, DE
• Walter Rittersdorf · Mannheim, DE
• Wolfgang Werner · Hersbruck, DE

Key dates

• Filing date: Jan 25, 1980
• Grant date: Oct 27, 1981
• Expiry date: Jan 25, 2000

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/904
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention provides a diagnostic agent for the detection of occult blood in feces comprising hydrogen peroxide and, as a chromogen, guaiaconic acid A, optionally with a stabilizer. The invention provides, as a novel substance, guaiaconic acid A having a specific extinction E.sub.1 cm.sup.1% at 600 nm of at least 200, determined by the reaction with peroxidase and hydrogen peroxide, having infra-red bands at PA0 1600 cm.sup.-1 (m); PA0 1505 cm.sup.-1 (v.s.); PA0 1206 cm.sup.-1 (s;b); PA0 1115 cm.sup.-1 (m); PA0 1025 cm.sup.-1 (m); and PA0 1200 cm.sup.-1 (s;b) and having an R.sub.F value of 0.45 (toluene/dioxan/glacial acetic acid; 90:25:10 v/v/v).