Substituted 4-amino-2,6-diaryl-tetrahydrothiopyrans and salts thereof, and use as antidepressants

US4297354A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Karl-Heinz Weber · Gau-Algesheim, DE
• Claus Schneider · Ingelheim am Rhein, DE
• Gerhard Walther · Bingen, DE
• Karl-Heinz Pook · Ingelheim am Rhein, DE
• Karin Boke · Ingelheim am Rhein, DE
• Wolf-Dietrich Bechtel · Appenheim, DE

Key dates

• Filing date: Dec 15, 1980
• Grant date: Oct 27, 1981
• Expiry date: Dec 15, 2000

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the steroisomeric formulas ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each phenyl, substituted phenyl, thienyl or furyl; PA1 R.sub.3 is hydrogen or straight or branched alkyl of 1 to 3 carbon atoms; and PA1 R.sub.4 is straight or branched alkyl of 1 to 3 carbon atoms; or PA1 R.sub.3 and R.sub.4, together with each other and the nitrogen atom to which they are attached, form a piperidino, 4-amino-piperidino, 4-(lower alkylamino)-piperidino, piperazino, 4-(alkyl of 1 to 2 carbon atoms)-piperazino or morpholino radical; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antidepressants.