4-(3,4-Diaminophenyl)pyridine or salts, and use thereof as cardiotonic
US4297362A · kind A · utility
5Cited by
2References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 28, 1980 |
| Grant date | Oct 27, 1981 |
| Priority date | — |
| Expiry date | Jul 28, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/38
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
4-(3,4-Diaminophenyl)pyridine, a cardiotonic agent, is prepared by reducing 4-(4-amino-3-nitrophenyl)pyridine or preferably by reacting 4-(4-acetylamino-3-nitrophenyl)pyridine or 4-(3-acetylamino-4-nitrophenyl)pyridine with stannous chloride and hydrochloric acid. 4-(3,4-diaminophenyl)pyridine or pharmaceutically-acceptable acid-addition salt thereof is disclosed as the active ingredient in a cardiotonic composition for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.