Bis-indole-alkaloid
US4298525A · kind A · utility
5Cited by
6References
1Claims
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Key dates
| Filing date | Jul 27, 1979 |
| Grant date | Nov 3, 1981 |
| Priority date | — |
| Expiry date | Jul 27, 1999 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of diindolealkaloids, especially new compounds corresponding to vinblastine or leurosine, in which the N-methyl group is replaced by an N--CH.sub.2 --OC.sub.2 H.sub.5 group having antitumor properties. The starting compounds are subjected to oxidation by chromic acid or an alkali metal dichromate at temperatures from -90.degree. C. to -30.degree. C. but preferably below about -45.degree. C. when the new compounds are to be produced, ethanol being present in this case.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.