Pharmaceutical preparations containing a polymeric agent for releasing 5-aminosalicylic acid or its salts into the gastrointestinal tract
US4298595A · kind A · utility
42Cited by
1References
38Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 29, 1979 |
| Grant date | Nov 3, 1981 |
| Priority date | — |
| Expiry date | Nov 29, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G65/48
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An intestinal anti-inflammatory preparation comprising a polymeric agent for releasing 5-aminosalicylic acid or its salts is disclosed. The polymeric agent comprises a nonabsorbable pharmacologically acceptable organic polymer backbone containing aromatic rings to which are covalently bonded via azo bonds a plurality of salicylic acid or salicylate salt groups. The azo bonds attach to the salicylates' 5-position carbon. The polymer's azo bonds undergo bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid and/or its salts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.