Preparation of (D-Trp .sup.6)-LH-RH via the heptapeptide H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH.sub.2
US4301066A · kind A · utility
2Cited by
2References
4Claims
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Key dates
| Filing date | May 8, 1980 |
| Grant date | Nov 17, 1981 |
| Priority date | — |
| Expiry date | May 8, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Herein is described a process for preparing the decapeptide Pry-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH.sub.2 ([D-Trp.sup.6 ]-LH-RH) by coupling Pyr-His-Trp-NHNH.sub.2 with H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH.sub.2. [D-Trp.sup.6 ]-LH-RH had been established to be an efficient agent for causing release of lutenizing hormone and follicle-stimulating hormone in mammals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.