Antigenic modification of polypeptides
US4302386A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 16, 1980 |
| Grant date | Nov 24, 1981 |
| Priority date | — |
| Expiry date | Jan 16, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/11
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Modified hormones or fragments of hormones are useful in producing antibodies when administered to an animal. Said antibodies in turn cause neutralization of endogenous natural protein hormones. The modification may be accomplished by attaching various kinds of modifying groups to the hormone or fragment. Modification may, for example, be achieved by chemically coupling diazosulfanilic acid groups to the hormone or fragment. The protein hormones to which this procedure can be applied are mammalian protein reproductive hormones such as, for example, Follicle Stimulating Hormone (FSH), or Human Chorionic Gonadotropin (HGG). These modified hormone or fragment may be administered to animals for the purpose of contraception, abortion, or treatment of hormone related disease states and disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.