Method for concentrating and purifying antihemophilic factor or factor VIII
US4302445A · kind A · utility
5Cited by
3References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 18, 1980 |
| Grant date | Nov 24, 1981 |
| Priority date | — |
| Expiry date | Jan 18, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is disclosed for concentrating and purifying antihemophilic factor (AHF or Factor VIII), a cryoprecipitate is collected from frozen human plasma and cold washed with pyrogen-free distilled water or water saline. The washed cryoprecipitate is extracted with pyrogen-free distilled water, the prothrombin complex is removed and the fibrinogen is precipitated. The remaining purified solution is ultrafiltered to form a highly concentrated Factor VIII solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.