Antiarrhythmic tetrahydronaphthalene derivatives
US4302453A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 9, 1980 |
| Grant date | Nov 24, 1981 |
| Priority date | — |
| Expiry date | Oct 9, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/70
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds are provided having the structure ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are hydrogen, lower alkyl, lower alkenyl, or hydroxy-lower alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached also form a heterocyclic radical which may contain another heteroatom, namely nitrogen, oxygen or sulfur; R.sup.3 and R.sup.4 may be the same or different and are hydrogen or lower alkyl. These compounds are useful in the treatment or arrhythmia. In addition, novel intermediates are provided having the structure ##STR2## wherein R is hydrogen, benzyl or ##STR3## These intermediates are also useful in treating acute myocardial infarction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.