Method and composition for determination of N-nitrosamines
US4303419A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 7, 1980 |
| Grant date | Dec 1, 1981 |
| Priority date | — |
| Expiry date | Jul 7, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S261/19
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
N-nitrosamines are reacted with a denitrosating agent to cleave the N-NO bond and yield nitric oxide which may be analyzed to determine both qualitatively and quantitatively, the N-nitrosamine content of a test sample. The denitrosating reagent has the advantage of being useful, even in the presence of substantial amounts of water, and comprises a mixture of glacial acetic acid and a concentrated inorganic acid which is either phosphoric acid or sulfuric acid. The volume ratio of glacial acetic to concentrated acid is within the ratio of from 1:2 to 5:1. This acid component mixture is combined with from about 0.1% to about 5% by weight of soluble inorganic bromide or iodide salt.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.