Heparin fragments having selective anticoagulation activity

US4303651A · kind A · utility

Assignee

• Kabi AB · SE

Inventors

• Ulf Lindahl · Uppsala, SE
• Gudrun Backstrom · Uppsala, SE
• John Y. L. Thunberg · Uppsala, SE
• Lars-Ake Fransson · Lund, SE
• Lars Andersson · Knivsta, SE
• Erik Holmer · Stockholm, SE
• Inga H. Sandberg
• Ewa G. Soderstrom · Saltsjöbaden, SE

Key dates

• Filing date: Jan 4, 1980
• Grant date: Dec 1, 1981
• Expiry date: Jan 4, 2000

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Heparin fragments having selective anticoagulation activity having 14-18 sugar units, the disaccharide unit L-iduronosyl-2-O-sulphate-N-sulpho-U-glucosamine-6-O-sulphate being the main component, and where unsulphated L-iduronic acid is in a position situated 3-5 sugar units from the unreducing terminal. Pharmaceutical compositions containing such heparin fragments. Processes for the preparation of the heparin fragments.