Pyrazolo[1,5-c]quinazoline derivatives and analgesic compositions containing them

US4303660A · kind A · utility

Assignee

• Egyt Gyogyszervegyeszeti GYAR · HU

Inventors

• Edit Berenyi nee Poldermann · Budapest, HU
• Eniko Szirt nee Kiszelly · Budapest, HU
• Peter Gorog · Budapest, HU
• Lujza Petocz · Budapest, HU
• Ibolya Kosoczky · Budapest, HU
• Agnes Kovacs nee Palotai · Budapest, HU
• Gabriella rmos nee Lassu · Budapest, HU

Key dates

• Filing date: May 16, 1980
• Grant date: Dec 1, 1981
• Expiry date: May 16, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel pyrazolo[1,5-c]quinazoline derivatives of the general formula I ##STR1## wherein R represents a hydrogen atom, a C.sub.1-4 alkyl group or an acyl group, PA1 R.sub.1 represents a hydrogen atom, a C.sub.1-12 alkyl group, a C.sub.3-8 cycloalkyl group, a C.sub.2-4 alkenyl group, an aralkyl group, wherein the alkyl group has 1 to 4 carbon atoms, a phenylalkenyl group, wherein the alkenyl group has 2 to 4 carbon atoms, furthermore a carboxy group or a phenyl group optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxy, C.sub.1-4 alkoxy, nitro or di(C.sub.1-4 alkyl)amino groups, or PA1 R and R.sub.1 may form together a valence bond, PA1 R.sub.2 represents a hydrogen atom, a C.sub.1-4 alkyl or a phenyl group, or PA1 R.sub.1 and R.sub.2 may form together a C.sub.2-7 alkylene group, PA1 R.sub.3 represents a nitro group, an amino group, an alkylamino group, a dialkylamino group, wherein the alkyl groups have 1 to 4 carbon atoms, an alkylideneimino group, wherein the alkylidene group has 1 to 4 carbon atoms, a benzylideneimino group or an acylamino group, PA1 and pharmaceutically acceptable acid addition salts th…