N-Propionylsarcosineanilides, process for their preparation, and pharmaceutical compositions containing them

US4303673A · kind A · utility

Assignee

• A NATTERMANN & CIE GMBH · DE

Inventors

• Jurgen Biedermann · Pulheim, DE
• Armin Wendel · Cologne, DE
• Hans Betzing · Kerpen, DE
• Volker Neuser · Bergheim, DE

Key dates

• Filing date: Sep 5, 1980
• Grant date: Dec 1, 1981
• Expiry date: Sep 5, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C323/36
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides N-propionylsarcosineanilides of the formula: ##STR1## wherein n is an integer of 1 to about 3 and the substituent A which can be the same or different when n is greater than 1 is selected from the group consisting of trifluoromethyl; halogen; nitro; acetyl; a straight-chain or branched alkyl group having 1 to 4 carbon atoms; a straight-chain or branched alkoxy group having 1 to 4 carbon atoms; a straight-chain or branched alkylmercapto group having 1 to 7 carbon atoms; a substituted alkylmercapto group of the formula: ##STR2## wherein n is an integer of 1 or 2, R.sub.1 can represent hydrogen and methyl, and R.sub.2 can represent hydroxyl, and an amino group of the formula: EQU --NR.sub.6 R.sub.7 V wherein R.sub.6 can represent hydrogen, and methyl, and R.sub.7 can represent methyl, substituted benzyl, and R.sub.6 and R.sub.7, together with the nitrogen, can constitute a substituted pyrrolidine ring; a sulphonyl group of the formula: EQU --SO.sub.2 R.sub.3 III wherein R.sub.3 can represent amino, and alkyl of 1 to 3 carbon atoms; or an aminoethoxycarbonyl group of the formula: ##STR3## wherein R.sub.4 and R.sub.5 which can be the same or different can represen…