Biphenylhydroxypropionic acid derivatives

US4304931A · kind A · utility

Assignee

• THE BOOTS COMPANY

Inventors

• John S. Nicholson · Beeston, GB
• John Turner · Berlin, DE

Key dates

• Filing date: Aug 2, 1979
• Grant date: Dec 8, 1981
• Expiry date: Aug 2, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process is disclosed for preparing arylpropionic acids of formula Ar--CH(CH.sub.3)--COOH, by reacting an aryl Grignard reagent with a metal pyruvate or with a pyruvamide, to form a hydroxy acid of formula Ar--C(OH)(CH.sub.3)--COOH or its amide, and converting the acid or amide to the product.