3-Aminosydnonimines, their preparation and use

US4305939A · kind A · utility

Assignee

• Cassella Aktiengesellschaft · DE

Inventors

• Karl Schonafinger · Alzenau, DE
• Rudi Beyerle · Frankfurt, DE
• Rolf-Eberhard Nitz · Frankfurt am Main, DE
• Piero Martorana · Bad Homburg vor der Höhe, DE
• Volker-Bernd Fiedler · Leverkusen, DE

Key dates

• Filing date: Jul 8, 1980
• Grant date: Dec 15, 1981
• Expiry date: Jul 8, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D271/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Physiologically-acceptable 3-aminosydnonimines of the formula ##STR1## and their pharmacologically-acceptable acid-addition salts, when formulated into medicament dosage forms, are useful for reducing systemic blood pressure, pulmonary artery pressure and left ventricular end diastolic pressure when orally administered to patients in need of such pressure reduction. These compounds are prepared by cyclizing a compound which, in its free-base state, is of the formula ##STR2## to a corresponding product which, in its free-base state, is of the formula ##STR3## and, when R.sup.2 is other than --H, acylating that product.