P-Tert.butylbenzotribromide and p-tert.butylbenzoyl bromide and process for their manufacture

US4306102A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Franz Landauer · Frankfurt am Main, DE
• Georg Schaeffer

Key dates

• Filing date: Nov 14, 1979
• Grant date: Dec 15, 1981
• Expiry date: Nov 14, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C51/093
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

p-Tert.butylbenzotribromide and the derivatives thereof which is halogen-substituted at the nucleus are prepared under side chain halogenation conditions by bromination of p-tert.butyltoluene and its derivatives substituted at the nucleus by halogen. Practically no undesired bromination in the nucleus or at the tert.butyl radical takes place. By partial saponification of the benzotribromide the corresponding benzoyl bromide is obtained. Further saponification of the latter or complete saponification of the benzotribromide yields p-tert.butylbenzoic acid and derivatives thereof which are halogen substituted at the nucleus, the esters of which can be used in pharmacology.