Method of maintaining the fluidity of hormone solutions for parenteral administration
US4306553A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 22, 1980 |
| Grant date | Dec 22, 1981 |
| Priority date | — |
| Expiry date | Jul 22, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of preventing the precipitation of hormone preparations within drug delivery systems that depend on the fluidity of the infusate for proper function. A non-toxic water soluble detergent is dissolved in the hormone solution prior to the introduction of the solution into the drug delivery system. The detergent is added in amount sufficient to prevent precipitation of the hormone during long-term storage in the drug delivery device. According to one form of usage, the hormone-detergent solution is charged to the pressurized drug storage chamber of an implanted infusion pump by injection through the patient's skin. As the solution is discharged from the delivery device by the constant pressure exerted upon the storage chamber, its low rate of flow is controlled by a restricted fluid passage. The solution is conveyed to an infusion site and diluted by the blood stream.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.