Material able to fix reversibly biologial macromolecules, its preparation and its application
US4308254A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 19, 1978 |
| Grant date | Dec 29, 1981 |
| Priority date | — |
| Expiry date | Sep 19, 1998 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2220/58
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A process for preparing a porous solid material for use in a chromatography column and which is capable of fixing reversibly biological macromolecules comprises coating a porous inorganic support with a polysaccharide polymer having .alpha.-glycol groups which undergo oxidative scission, subjecting the polysaccharide polymer to an oxidative scission reaction, reacting the resulting oxidized polysaccharide polymer with an amino molecule or macromolecule having the formula R'--NH.sub.2 to produce a polysacchride polymer having the formula R.sub.4 --CH.dbd.N--R' and reducing the imine bond in said immediately above defined polysaccharide polymer to a stable amine bond.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.