1,2,4-Oxadiazine derivatives, process for their preparation and pharmaceutical compositions containing them
US4308270A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 10, 1980 |
| Grant date | Dec 29, 1981 |
| Priority date | — |
| Expiry date | Oct 10, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns new compounds of the general formula (I) ##STR1## wherein R.sup.1 is hydrogen or phenyl optionally substituted by one or more of the following substituents: alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro; PA1 R.sup.2 is alkyl having 1 to 4 carbon atoms, cycloalkyl having 5 to 7 carbon atoms or phenyl, optionally substituted with one or more of the following groups: alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro; or R.sup.2 is a naphthyl group; PA1 R.sup.3 is alkyl having 1 to 4 carbon atoms, acyl or hydrogen; PA1 R.sup.4 hydrogen or alkyl having 1 to 4 carbon atoms; PA1 R.sup.5 is cycloalkyl having 5 to 7 carbon atoms, alkyl having 1 to 6 carbon atoms, phenyl-(C.sub.1-4 -alkyl) in which the phenyl moiety may optionally be substituted with alkoxy having 1 to 4 carbon atoms, halogen or nitro; PA1 or R.sup.4 and R.sup.5 together represent a group of the general formula (V) ##STR2## wherein R.sup.6 is hydrogen or alkoxy having 1 to 4 carbon atoms, m and n stand for 0, 1 or 2 PA1 and acid addition and quaternary salts thereof. The compounds of the general formula (I) are potent periphera…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.