Compounds of the pregnane series with an oxygen function in the 19-position, processes for their manufacture and pharmaceutical preparations containing these compounds
US4309423A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 8, 1980 |
| Grant date | Jan 5, 1982 |
| Priority date | — |
| Expiry date | Feb 8, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0094
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
19-Oxygenated steroid compounds of the pregnane series of the formula I ##STR1## in which R.sup.1 represents a hydrogen atom, and PA1 R.sup.2 represents an .alpha.-oriented lower alkanoylthio group, or PA1 R.sup.1 and R.sup.2 together represent a carbon-carbon bond or an .alpha.-or .beta.-oriented methylene radical, PA1 R.sup.3 represents a free hydroxymethyl group or a hydroxymethyl group etherified by a lower alkyl or esterified by a lower alkanoyl; or represents a formyl group, a carboxyl group or a lower alkoxycarbonyl group, and PA1 R.sup.4 represents a hydrogen atom or the acyl radical Ac of a carboxylic acid, and corresponding 1,2-dehydro derivatives have valuable aldosterone-antagonizing properties with a minimum effect on sexual functions. As the compounds reduce the excessive sodium retention and potassium excretion induced by aldosterone, they are especially useful as the active ingredient in pharmaceutical preparations for alleviating diseases involving hyperaldosteronismus in man and other warm-blooded animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.