Antisecretory guanidine derivatives and pharmaceutical compositions containing them
US4309435A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Oct 10, 1979 |
| Grant date | Jan 5, 1982 |
| Priority date | — |
| Expiry date | Oct 10, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/48
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a guanidine derivative of the formula I: EQU Het.sup.1 -(CH.sub.2).sub.m -Y.sup.1 -(CH.sub.2).sub.n -NR.sup.1 -A-NR.sup.2 -(CH.sub.2).sub.q -Y.sup.2 -(CH.sub.2).sub.p -Het.sup.2 I in which Y.sup.1 and Y.sup.2 are O, S, direct bonds, CH.sub.2 or SO; m and p are 0 to 4, n and q are 1 to 4, provided that when Y.sup.1 or Y.sup.2 is O, S or SO, m or p is 1 to 4 and provided that when Y.sup.1 or Y.sup.2 is O or SO, n or q is 2 to 4; one of R.sup.1 and R.sup.2 is hydrogen and the other is hydrogen or C.sub.(1-6) alkyl; A is 3,4-dioxocyclobuten-1,2-diyl or C.dbd.Z in which Z is S, O, NCN, NNO.sub.2, CHNO.sub.2, NCONH.sub.2, C(CN).sub.2, NCOR.sup.3, NCO.sub.2 R.sup.3 NSO.sub.2 R.sup.3 or NR.sup.4 in which R.sup.3 is C.sub.(1-6) alkyl or C.sub.(6-12) aryl and R.sup.4 is hydrogen or C.sub.(1-6) alkyl or when R.sup.1 and R.sup.2 are hydrogen A is EQU -A.sup.1 -E.sup.1 -G-E.sup.2 -A.sup.2 - II in which A.sup.1 and A.sup.2 are 3,4-dioxocyclobuten-1,2-diyl or C.dbd.Z.sup.1 and C.dbd.Z.sup.2 in which Z.sup.1 and Z.sup.2 are the same as Z, E.sup.1 and E.sup.2 are O or S or NH optionally substituted by C.sub.(1-10) alkyl, C.sub.(3-10) alkenyl, C.sub.(3-10) alkynyl, C.sub.(3-…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.