Process for the preparation of bis-indole alkaloids and acid-addition salts thereof and methods of treating tumors with bis-indole alkaloids
US4310528A · kind A · utility
4Cited by
4References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 8, 1980 |
| Grant date | Jan 12, 1982 |
| Priority date | — |
| Expiry date | Apr 8, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of diindole-alkaloids, especially new compounds corresponding to vinblastine or leurosine, in which the N-methyl group is replaced by an N--CH.sub.2 --O--R group wherein R is lower alkyl, having antitumor properties. The starting materials are subjected to oxidation by chromic acid or an alkali metal dichromate at temperatures from -90.degree. C. to -30.degree. C. and preferably below -45.degree. C. where the new compounds are to be produced, a lower alkanol being present in this case.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.