Solvent mixing in HPLC using low pressure solvent metering pumps
US4311586A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 22, 1980 |
| Grant date | Jan 19, 1982 |
| Priority date | — |
| Expiry date | Apr 22, 2000 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D15/163
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A liquid chromatograph for HPLC utilizes low pressure solvent metering pumps for solvent mixing in series with a high pressure pump driving the column. Solvent mixture is provided at a flow based upon the intake demand of the high pressure pump. Such operation is obtained by the use of flow control apparatus disposed between the solvent metering pumps and the high pressure pump. The flow control apparatus includes a detector cell disposed in the solvent mixture flow path between the metering pumps and the high pressure pump. The cell has an inlet port for receiving an input flow of solvent mixture into the cell from the solvent mixing means, an outlet port for withdrawal of an output flow of solvent mixture by the high pressure pumps, and a reservoir between the inlet and outlet ports for holding a volume of solvent mixture accumulated in an amount dependent upon the relative flow rates of the cell input and output flow. The cell having first and second spaced-apart electrodes in contact with the solvent mixture accumulated in the cell. One of the electrodes receives an applied electrical excitation. The other electrode senses the applied excitation through the accumulated solvent …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.