Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4311705A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 1980 |
| Grant date | Jan 19, 1982 |
| Priority date | — |
| Expiry date | Oct 6, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/5456
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds, compositions and method of alleviating hypertension using a compound of the formula ##STR1## wherein R is hydrogen or lower alkyl; PA1 R.sub.1 is hydrogen, lower alkyl or phenyl-lower alkyl; PA1 R.sub.2 is hydrogen, lower alkyl or phenyl lower alkyl or halo substituted lower alkyl; PA1 R.sub.3 is hydroxy, --NHOH or lower alkoxy; PA1 Pr-COOR is a substituted proline of the structures ##STR2## R.sub.4 is halogen, keto, azido, cycloalkyl, phenyl, substituted phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, ##STR3## or Y--R.sub.6 ; R.sub.5 is hydrogen or lower alkyl; PA1 Y is oxygen or sulfur; PA1 R.sub.6 is lower alkyl, phenyl, substituted phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, 1- or 2-naphthyl, substituted 1- or 2- naphthyl, biphenyl, or substituted biphenyl; PA1 R.sub.7 is halogen or --Y--R.sub.8 ; PA1 R.sub.8 is lower alkyl, phenyl, phenyl-lower alkyl substituted phenyl-lower alkyl, biphenyl, napthyl, or the R.sub.8 groups join to complete an unsubstituted 5- or 6-membered ring or such ring wherein one or more carbon atoms are substituted by a lower alkyl or di(lower alkyl) group; PA1 R.sub.9 is keto, phenyl, 2- or 4-hydroxyphenyl; PA1 n i…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.