2,5-Inter-o-phenylene-3,4-dinor-5,9.alpha.-epoxy-9-deoxy-PGF.sub.1 compounds
US4312810A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 31, 1979 |
| Grant date | Jan 26, 1982 |
| Priority date | — |
| Expiry date | Jul 31, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/5456
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to certain structural and pharmacological analogs of prostacyclin (PGI.sub.2) and 5,6-dehydroprostacyclin (PGI.sub.1) and 5,9.alpha.-epoxy-9-deoxy-PGF.sub.1, wherein between the position beta to the carboxy (C-2) and C-5 there is substituted an inter-o-phenylene for the ethylene chain. These novel 2,5-inter-o-phenylene-3,4-dinor-prostaglandin or prostacyclin-type compounds are useful for certain of the same pharmacological purposes as prostacyclin, particularly being smooth muscle stimulators, blood pressure depressors and platelet aggregation inhibitors. Also provided are novel intermediates therefor, namely corresponding interphenylene-containing PGF.sub.2.alpha. and 5-halo-PGI.sub.1 and 6-halo-5,9.alpha.-epoxy-9-deoxy-PGF.sub.1 compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.