Pharmaceutical compositions containing N-alkyl-N-(nuclearly-substituted) benzylamines having vasotonia-regulating activity

US4312861A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Istvan Boksay · Kiedrich, DE
• Alfons Soder · Kelsterbach, DE
• Volkher Bollmann · Erbach, DE
• Rolf-Ortwin Weber · Niedernhausen, DE

Key dates

• Filing date: Jun 13, 1977
• Grant date: Jan 26, 1982
• Expiry date: Jun 13, 1997

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Aralkylamines of the formula: EQU R.sup.1 --CH.sub.2 --N(R.sup.3)--R.sup.2 wherein PA1 R.sup.1 is a phenyl substituted by one of: PA2 (I) alkyls, PA2 (II) halo and PA2 (III) nitro; PA1 R.sup.2 is PA2 (IV) alkyl having from 4 to 10 carbon atoms, four of which are in one chain, PA2 (V) alkyl interrupted by an oxygen atom, i.e. an alkoxyalkyl or ether radical, or PA2 (VI) hydroxyalkyl wherein the alkyl is either (IV) or (V) and the hydroxy is the sole substituent; PA1 R.sup.3 is a hydrogen atom, alkyl having from 1 to 4 carbon atoms or such alkyl substituted by a dialkylphosphinyl group; a physiologically-compatible acid-addition salt thereof and a pharmaceutical composition containing such compound(s) as active ingredient(s) are valuable in view of the physiological activity, e.g. vasotonic, capillary sealing and antiarrhythmic, of the aralkylamines and their physiologically-compatible acid-addition salts.