Combination apparatus and method for chromatographic separation and quantitative analysis of multiple ionic species
US4314823A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 13, 1979 |
| Grant date | Feb 9, 1982 |
| Priority date | — |
| Expiry date | Sep 13, 1999 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/25375
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Apparatus and method for chromatographic separation and quantitation of different ions of like charges in a sample, e.g., cations or anions. Referring to anion separation, the sample is directed to a first chromatographic column of the ion exclusion type in which the weak acids (e.g., carboxylic acids) and their salts are partially or totally resolved and separated from a fraction of strong acids (e.g., mineral acids) due to Donnan exclusion. The resolved weak acids may be passed directly to a conductivity cell for quantitative detection. The strong acids may be directed to anion exchange bed with a highly ionized developing reagent and eluted in resolved form with the effluent being passed to a suppressor ion exchange bed wherein the developing reagent is converted to a weakly ionized form without destroying the anion separation. Then, a fraction of the strong acids is detected with the same or a different conductivity cell. Prior to separation, the strong acids are preferably directed through a concentrator column formed of ion exchange resin in which they are retained but not resolved while the remaining solution is removed. Thereafter, the developing agent used for separation o…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.