Process for obtaining a plasminogen activator
US4314994A · kind A · utility
15Cited by
1References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 24, 1980 |
| Grant date | Feb 9, 1982 |
| Priority date | — |
| Expiry date | Jul 24, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to an improved process for the preparation of plasminogen activator. This is a process for separating a plasminogen activator according to U.S. Pat. No. 3,998,947 characterized in that it comprises at least the following stages: PA0 (i) selective adsorption of the said activator on a support with specific affinity comprising soluble fragments of fibrin covalently bonded to an insoluble matrix; and PA0 (ii) elution of the activator from the fibrin bearing the adsorbed activator. The plasminogen activator obtained is useful in the prevention and treatment of thrombosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.