Terminal amino prostaglandin analogues
US4315022A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 23, 1980 |
| Grant date | Feb 9, 1982 |
| Priority date | — |
| Expiry date | May 23, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/86
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula (I): ##STR1## having pharmacological activities similar to those of natural prostaglandins wherein: PA1 n is 0 to 5; PA1 X is CO, CS or CH.sub.2 ; PA1 Y is --CH.sub.2 --CH.sub.2 --; or, when n is 1 to 5, --CH.dbd.CH-- or --C.tbd.C--; PA1 R.sub.1 is either CH.sub.2 NR.sub.5 R.sub.6, wherein R.sub.5 and R.sub.6 are separately hydrogen or C.sub.1-6 alkyl, or R.sub.5 is hydrogen and R.sub.6 is (CH.sub.2).sub.m CO.sub.2 R.sup.1.sub.9 wherein m is 0 to 4 and R.sup.1.sub.9 is optionally substituted C.sub.1-6 alkyl or benzyl, optionally substituted in the phenyl ring by chlorine or bromine atoms or by nitro or CF.sub.3 groups; or R.sub.5 and R.sub.6 are both the same (CH.sub.2).sub.m CO.sub.2 R.sup.1.sub.9 as hereinbefore defined; or C(NH.sub.2).dbd.NOH; or C(OR.sub.7).dbd.NH.sub.2.sup.+ B.sup.- wherein R.sub.7 is C.sub.1-6 alkyl and B.sup.- is a salting ion; or CH.sub.2 NHR.sub.8, wherein R.sub.8 is SO.sub.2 R.sup.1.sub.9, COR.sup.1.sub.9 or CZNHR.sub.9 and R.sup.1.sub.9 is as hereinbefore defined, R.sub.9 is hydrogen or C.sub.1-6 alkyl and Z is oxygen or sulphur; or CZNH.sub.2 wherein Z is as hereinbefore defined: PA1 R.sub.2 is hydrogen or C.sub.1-4 alkyl; PA1 R…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.