4-Phenyl-4,5,6,7-tetrahydro-pyrrolo [2,3-c] pyridines and salts thereof

US4315938A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Claus Schneider · Ingelheim am Rhein, DE
• Karl-Heinz Weber · Gau-Algesheim, DE
• Gerhard Walther · Bingen, DE
• Karin Boke · Ingelheim am Rhein, DE
• Wolf-Dietrich Bechtel · Appenheim, DE

Key dates

• Filing date: Jun 30, 1980
• Grant date: Feb 16, 1982
• Expiry date: Jun 30, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.2 is hydrogen, chlorine, bromine, formyl, acetyl, alkyl of 1 to 4 carbon atoms, nitro, cyano or --CH.sub.2 --A; where PA1 A is (alkyl of 1 to 2 carbon atoms)-amino; di(alkyl of 1 to 2 carbon atoms)-amino, where one of the alkyl moieties may have a terminal hydroxyl substituent attached thereto; or a 5-, 6- or 7-membered saturated, nitrogen-containing heterocycle which is attached to the methylene group through the nitrogen atom and may have a hydroxyl or hydroxymethyl substituent attached to a ring carbon atom, and the 6-membered heterocycle may contain oxygen as an additional ring heteroatom in the p-position; PA1 R.sub.3 is hydrogen, fluorine, chlorine, bromine, methyl or methoxy; and PA1 R.sub.4 is hydrogen or alkyl of 1 to 3 carbon atoms; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antidepressants.