Cephalosporin intermediates
US4316016A · kind A · utility
1Cited by
12References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 11, 1980 |
| Grant date | Feb 16, 1982 |
| Priority date | — |
| Expiry date | Jun 11, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In the preferred embodiment of the present invention trimethylsilyl 7-trimethylsilyloxycarbonylaminodecephalosporanate was prepared by bubbling dry carbon dioxide into an ahydrous solution of trimethylsilyl 6-trimethylsilylaminodecephalosporanate and found to be a useful intermediate in the production of cefadroxil and cephalexin by its acylation in anhydrous media with the appropriate 2-phenylglycyl chloride hydrochloride. Other cephalosporins are produced by acylation of 7-trimethylsilyloxycarbonylaminoceph-3-em-4-carboxylic acids or esters having a variety of substituents at the 3-position.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.