Peptides and processes for the manufacture thereof
US4316890A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 10, 1980 |
| Grant date | Feb 23, 1982 |
| Priority date | — |
| Expiry date | Mar 10, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The somatostatin-analogous peptides according to the invention of the general formula ##STR1## in which Bmp represents the desaminocysteine radical PA1 X represents Asn or His, PA1 trp represents D-Trp that may be substituted in the benzene ring by a halogen atom, and PA1 Y represents the radical of a secondary .alpha.-amino acid having a maximum of 8 carbon atoms and the corresponding peptide amides and also acid addition salts and complexes thereof are distinguished by strong insulin-antagonistic and glucagon-antagonistic effects and are therefore therapeutically acceptable, preferably in the form of pharmaceutical preparations, in similar indications to those of somatostatin, especially also as antidiabetics. The compounds are manufactured by conventional processes of peptide synthesis, especially by liberation from corresponding protected intermediates and by the formation of the cystine disulphide bridge by means of oxidation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.