Preparation of 4-fluoro-3-phenoxy-toluene

US4316994A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Rainer Fuchs · Halver, DE
• Fritz Maurer · Wuppertal, DE
• Uwe Priesnitz · Solingen, DE
• Hans-Jochem Riebel · Bad Camberg, DE

Key dates

• Filing date: Jul 18, 1980
• Grant date: Feb 23, 1982
• Expiry date: Jul 18, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C43/29
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of 4-fluoro-3-phenoxytoluene of the formula ##STR1## comprising reacting 3-bromo-4-fluoro-toluene of the formula ##STR2## with an alkali metal or alkaline earth metal phenolate in the presence of copper as catalyst and in the presence if isoquinoline as diluent at a temperature between about 100.degree. and 200.degree. C. Advantageously the reaction is effected in the presence of about 0.9 to 1.5 mols of potassium or magnesium carbonate, about 1 to 1.2 mols of the phenolate, about 1 to 50 g of copper, copper(I) oxide, copper(I) chloride or copper (I) bromide as catalyst and about 150 to 1,500 ml of isoquinoline per mol of 3-bromo-4-fluoro-toluene.