Indolyl and methylindolyl substituted aminoalkyl guanidines

US4317832A · kind A · utility

Inventors

• Karl H. Klingler · Langen, DE
• Axel Kleemann · Hanau, DE
• Fritz Stroman · Offenbach, DE
• Klaus Thiemer · Hanau, DE

Key dates

• Filing date: Sep 5, 1979
• Grant date: Mar 2, 1982
• Expiry date: Sep 5, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/88
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds corresponding to the formula ##STR1## are disclosed, wherein Alk represents a C.sub.2 -C.sub.5 -alkylene groups optionally substituted by a hydroxy group and Ar represent an optionally substituted phenyl, naphthyl, tetrahydronaphthyl, indanyl or indenyl radical or a monocyclic or condensed bicyclic or tricyclic heterocyclic radical which is optionally substituted, the heterocyclic radical consisting of individual rings having 5 or 6 members and optionally containing from 1 to 4 hetero atoms, and the acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyl guanidines block the .beta.-receptors of the adrenergic nerve system, and also reduce blood pressure.