Suspension of microencapsulated bacampicillin acid addition salt for oral, especially pediatric, administration
US4321253A · kind A · utility
35Cited by
6References
12Claims
0Family size
Inventor
Key dates
| Filing date | Aug 22, 1980 |
| Grant date | Mar 23, 1982 |
| Priority date | — |
| Expiry date | Aug 22, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel formulation of bacampicillin for oral administration is disclosed. Microcapsules comprising an acid addition salt of bacampicillin coated with a mixture of ethyl cellulose:water-soluble or water-permeable filler material are suspended in a buffered vehicle having a pH of at least 6.9. The novel suspension is characterized by palatable taste, surprisingly good stability and enhanced bioavailability after oral administration. The novel suspension is well suited for multiple dose oral administration. The preferred filler material is hydroxypropyl cellulose.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.