Implantable drug depot and process for the production thereof

US4322398A · kind A · utility

Assignee

• Battelle Institute e.V. · DE

Inventors

• Roland Reiner · Basel, CH
• Wolfgang KiBing · Treffurt, DE
• Helga Doring · Cologne, DE
• Kari Koster-Losche · Usingen, DE
• Helmut Heide · Kelkheim, DE

Key dates

• Filing date: Feb 21, 1979
• Grant date: Mar 30, 1982
• Expiry date: Feb 21, 1999

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An implantable drug depot for the treatment of diseases of the bone or bone marrow. The depot consisting of a matrix in which at least one active ingredient is incorporated and contains at least one adjuvant agent to control the kinetics of the drug release. The matrix material consists of resorbable sintered calcium phosphate composed of CaO and P.sub.2 O.sub.5 in a ratio between 5:1 and 2:1.